Selected for Faculty of 1000 (Factor 3 Recommended). Fun fact: Like many Swedish people, Eric has completed Vasaloppet, a 60-mile cross-country skiing race (twice!). Chem. In mature animals, cells and organs interact to maintain homeostasis and coordinate their physiological roles. Derr A, Yang C, Zilionis R, Sergushichev A, Blodgett DM, Redick S, Bortell R, Luban J, Harlan DM, Kadener S, Greiner DL, Klein A, Artyomov MN, Garber M. End Sequence Analysis Toolkit (ESAT) expands the extractable information from single-cell RNA-seq data. J. Biol. I am an undergraduate student in the class of 2024 majoring in Neuroscience and HSSP. Kadener S., Fededa J.P., Rosbash M. and Kornblihtt A.R. RNA biology Neurosciences. Further, our work and that of others has suggested functions of these moleculesin vivo. We use Drosophila as a model system to characterize the mechanisms underlying communication between cells, tissues, and organs. Cohen-Hadad Y., Altarescu G., Eldar-Geva T., Levi-Lahad E., Zhang M., Rogaeva, E. Gotkine M., Bartok O., Ashwal-Fluss R., Kadener S., Epsztejn-Litman S., Eiges R. Marked differences in C9orf72 methylation status and isoform expression between C9/ALS human embryonic and induced pluripotent stem cells. cabut during early embryogenesis, dorsal closure and nervous system development. He received his BS in Biochemistry and Molecular Biology in 2022 from Dickinson College in Carlisle Pennsylvania. Proximity labeling-based methods coupled with mass spectrometry (MS) offer a high-throughput approach for systematic analysis of spatially-restricted proteomes. The tagged endogenous proteins can then be isolated for further analysis by MS. To analyze protein-protein interactions or identify components that localize to discrete subcellular compartments, we developed tools based on. Laboratory Profile Principal Investigator: Sebastian Kadener A systemic view of circadian clocks: from gene expression to neuronal networks and behavior. Nogues G., Kadener S., Cramer P., Bentley D. and Kornblihtt A.R. Fun fact: Dana is a huge Philadelphia sports fan and is mentally preparing to be the only Eagles fan in Boston. 2012- Lab manager at Ami Citri laboratory at the Hebrew University of Jerusalem 2010- 2012 Postdoc at the Hebrew University of Jerusalem at Sebastian Kadener Lab; research topic-studying neodegenerative diseases using fruit flies as a model 2000-2003 Research assistant at QBI company; I was part of research We renamed the center DRSC/TRiP-Functional Genomics Resources to better represent our current capabilities. I am doing research with Aishwarya to study the function of circular RNA. In addition to ImpL2, we have also identified two additional factors produced from yki-gut tumors that contribute to tissue wasting: the Pvr receptor tyrosine kinase ligand Pvf1 and the IL6-like cytokine Unpaired 3 (Upd3). 1, Artyomov M., Shishkin A., Kadri S., Zhu X., Gutman M., Garber M.* and Kadener S.* Defining the 5 and 3 landscape of theDrosophilatranscriptome with ExoCAGE and RNaseH-seq. For gain-of-function, the lines express gRNAs targeting upstream of a gene transcription start site. We are now using this tool to establish sensors of each signaling pathway involved in gut homeostasis, and will use these reagents to examine pathway crosstalk. In this context, the most important question looking forward are: Afik S. 1, Bartok O. Bartok O., Teesalu M., Pandey V., Hanan M., Poukkula M., Havula E., Moussaieff A., Vodala S., Nahmias Y., Kadener S.* and Hietakangas V.* Cabut-dependent repressive branch of the sugar sensing transcriptional network regulates glyceroneogenesis. We are now adapting the pooled-format CRISPR screening approach for use in cell lines from medically relevant mosquito species. She is the Co-Director of Research for a non-profit, the STEM Advocacy Institute, which is focused on building a future where there is equitable access and exposure to science for all people. Portal D., Lobo G.S., Kadener S., Prasad J., Espinosa J.M., Pereira C.A., Tang Z., Lin R.J., Manley J.L., Kornblihtt A.R., Flawia M.M. Our major contributions to tool development are the Gal4-UAS system, FLP-FRT germline clone technique, in vitro and in vivo genome-wide RNAi and CRISPR screening platforms and resources, and in vivo proximity labeling methods. Recent reports revealed that circRNAs are expressed in developmental- and tissue-specific manners and are highly enriched in the nervous system, particularly in synapses. Wittenbrink N, Ananthasubramaniam B, Mnch M, Koller B, Maier B, Weschke C, Bes F, de Zeeuw J, Nowozin C, Wahnschaffe A, Wisniewski S, Zaleska M, Bartok O, Ashwal-Fluss R, Lammert H, Herzel H, Hummel M, Kadener S, Kunz D, Kramer A. Levin-Klein R., Fraenkel S., Lichtenstein M., Matheson L., Bartok O., Nevo Y., Kadener S., Corcoran A., Cedar H., Bergman Y. These studies have allowed us to better characterize what cell types are present in different gut regions and provide us with new powerful data sets with which we can better characterize the transcriptional networks that define lineage relationships among cell types, cell-cell interactions among cell types (i.e. *, Afik S., Menet J., Wolfson V., Weissbein U., Haimovich D., Gafni C., Friedman N., Rosbash M. and Kadener S. . High-accuracy determination of internal circadian time from a single blood sample. Fun fact: Anna is a gardening nerd on hold, as she does not have a garden in Boston. Community support Reprint. Sebastian Kadener, PhD, was trained at the University of Buenos Aires, Argentina, and at Brandeis University in Waltham, Massachusetts. In the Bandopadhay Lab, Marissa is working to study drivers of Diffuse Midline Gliomas, including the mechanisms through which MYC isoforms are activated. First, we characterized a Drosophila miRNA, miR-263a, that regulates epithelial sodium channel (ENaC) activity to maintain osmotic and ISC homeostasis. S Kadener, P Cramer, G Nogus, D Cazalla, M de la Mata, JP Fededa, . Before joining the Bando Lab, John worked as a High Frequency Trader. Coordination between transcription and pre-mRNA processing. Kadener S., Fededa J.P., Rosbash M. and Kornblihtt A.R. Aaron is an Attending Pediatric Neuro-Oncologist at the Dana-Farber/Boston Childrens Cancer and Blood Disorders Center. BOX 39.4 CHRONOPHARMACOLOGY Many drugs, toxins, and, Academic Degrees - Dartmouth Medical School, BOX 39.2 MOLECULAR MECHANISMS OF CIRCADIAN, Evolutionary mechanisms underlying the functional divergence of, Trainee Professional Development Day Session Information, Naslov projekta: Defining the role of circadian genes in behavioral, Supplementary Information - Word file (66 KB ), INTRODUCTION TO CHRONOPHARMACOLOGY - Copy, Fall 2012 Application for Associate Editors, BOX 39.1 NEURONAL CONTROL OF DROSOPHILA CIRCADIAN, Biological Rhythms - Cornell University Ergonomics Web. Associate Professor, Brandeis University. Cohen-Hadad Y., Altarescu G., Eldar-Geva T., Levi-Lahad E., Zhang M., Rogaeva, E. Gotkine M., Bartok O., Ashwal-Fluss R., Kadener S., Epsztejn-Litman S., Eiges R. Marked differences in C9orf72 methylation status and isoform expression between C9/ALS human embryonic and induced pluripotent stem cells. Second, we identified 53 transcription factors, specifically expressed or enriched in the ISCs, and are characterizing how they cooperate to integrate signal inputs. Bartok O., Teesalu M., Pandey V., Hanan M., Poukkula M., Havula E., Moussaieff A., Vodala S., Nahmias Y., Kadener S.* and Hietakangas V.* Cabut-dependent repressive branch of the sugar sensing transcriptional network regulates glyceroneogenesis. Lacadie S.A., Tardiff D.F., Kadener S. and Rosbash M. In vivo commitment to yeast cotranscriptional splicing is sensitive to transcription elongation mutants. Fun fact: Maddie is a multimedia artist and during quarantine, Maddie collaged all of the wooden furniture in her apartment. In a collaboration with Sebastian Kadeners lab at Brandeis, we generated a new set of PspCas13b and RfxCas13d expression constructs that can be used to target RNA in cells and in vivo. Adam grew up in Ethiopia and moved to Bremen, Germany where he received his B.Sc and M.Sci in Biochemistry and Cell Biology from Jacobs University which was his very first exposure to the exciting field of epigenetics. Did you find mistakes in interface or texts? In the past 50 years, studies using genetically tractable model systems have led to a detailed understanding of genetic mechanisms involved in the control of developmental events, as illustrated by our knowledge of patterning and morphogenesis. Olivia received her B.A. This collection is available to the community through the Bloomington Drosophila Stock Center. Fsica, Tcnico Sup. Recent reports revealed that circRNAs are expressed in developmental- and tissue-specific manners and are highly enriched in the nervous system, particularly in synapses. SRCP: a comprehensive pipeline for accurate annotation and quantification of circRNAs. Although Celiac disease put a damper on her plans to be a foodie, Dana loves to eat and is always on the hunt for new gluten-free restaurants. An early ancestor in the evolution of splicing: a. Nogues G., Kadener S., Cramer P., de la Mata M., Fededa J.P., Blaustein M., Srebrow A. and Kornblihtt A.R. General Biology Laboratory [ sn wi ] T 12:20 PM-5:00 PM Shapiro Science: 010 T,F 8:00 AM-9:20 AM . Moreover, in 2019, we were funded to function as the Drosophila Research and Screening Center-Biomedical Technology Research Resource (DRSC-BTRR), which focuses on development of new screening and other technologies. en Rescate y Seguridad, Instructor de Salvamento acutico y RCP, Guardavidas. Portal D., Lobo G.S., Kadener S., Prasad J., Espinosa J.M., Pereira C.A., Tang Z., Lin R.J., Manley J.L., Kornblihtt A.R., Flawia M.M. @skadener. Despite the importance of antibodies in biology study, antibodies are not available for most fly proteins. NanoTags, VHH05- and 127D01-tagsthat are 14 and 10 amino acids in length, and their corresponding nanobodies (NbVHH05 and Nb127D01) are excellent reagents for both, We have developed a series of bioinformatics tools that provide the research community with well-designed, user-friendly resources that impact research at all stages, from project design to data analysis and integration. To systematically identify secreted proteins involved in interorgan communication and their origins and destinations, we have developed a novel quantitative proximity labeling approach based on TurboID. Circadian clocks are remarkably robust: they are able to keep time without timing cues and are resilient to large variations in environmental conditions. Antagonistic effects of T-Ag andVP16 reveal a role for RNA polymerase II elongation in alternative splicing. Chikne V.*, Doniger T.*, Bartok O. Simchovitz A, Hanan M, Niederhoffer N, Madrer N, Yayon N, Bennett ER, Greenberg DS, Kadener S, Soreq H. Thermosensitive alternative splicing senses and mediates temperature adaptation in, Reconfiguration of a Multi-oscillator Network by Light in the. de la Mata M., Alonso C.R., Kadener S., Fededa J.P., Blaustein M., Pelisch F., Cramer P., Bentley D. and Kornblihtt A.R. Pvf1 produced by yki-gut tumors activates MEK/ERK signaling and enhances catabolism in multiple tissues. Zaffagni M, Kadener S. NEAT1 is overexpressed in Parkinson's disease substantia nigra and confers drug-inducible neuroprotection from oxidative stress. Coordination between transcription and pre-mRNA processing. Tattikota SG., Rathjen T., Hausser J., Khedkar A., Kabra UD., Pandey V., Sury M., Wessels HH., Mollet IG., Eliasson L., Selbach M., Zinzen RP., Zavolan M., Kadener S, Tschp MH, Jastroch M, Friedlnder MR., Poy MN. Fededa J.P., Petrillo E., Gelfand M.S., Neverov A.D., Kadener S., Nogues G., Pelisch F., Baralle F.E., Muro A.F. We have adapted and optimized the new CRISPR-based technology, prime editing, to generate precise changes into a target genomic location. Weiss R., Bartok O., Mezan S., Malka Y and Kadener S. Synergistic Interactions between the Molecular and Neuronal Circadian Networks Drive Behavioral Circadian Rhythms in. Feel free to send suggestions. Stelzer Y., Bar S., Bartok O., Afik S., Ronen D., Kadener S.* and Benvenisty N.* Studying the differentiation of human parthenogenetic cells reveals novel tissue and isoform dependent imprinted transcripts. One of these translated circRNAs is circMbl. He also enjoys playing handball and online chess. Control of alternative pre-mRNA splicing by RNA Pol II elongation: faster is not always better. Elife 8. Finally, as an alternative to RNAi for partial loss-of-function screens using a Cas system, we have shown that Cas13 is an effective tool for CRISPRi in Drosophila cells. Lerner I. Our lab is interested in determining how molecular and neural circadian components regulate each other and generate a system that is both robust and plastic. Contact the author . Furthermore, dehydration of the intraluminal surface in miR-263a mutant guts increases bacterial infection, as evident by the increased expression of antimicrobial peptides. For example, we showed that circRNA biogenesis competes with canonical splicing, showing that circRNAs can function incisas RNA traps. Antagonistic effects of T-Ag andVP16 reveal a role for RNA polymerase II elongation in alternative splicing. using proximity labeling to identify all proteins secreted by the tumors. Fun fact: Michelle is a huge Stephen King fan. . Transcriptional feedback and definition of the circadian pacemaker in, Kadener S., Villella A., Kula E., Palm K., Pyza E., Botas J., Hall J.C. and Rosbash M. Neurotoxic protein expression reveals connections between the circadian clock and mating behavior in. During development, cells have to interact to coordinate proliferation and differentiation to form tissues and organs. Maddie received her MS and BS in Biology from Brandeis University in 2021. Lic. She also loves sleeping in, making guacamole, and reading about art history. Selected for Faculty of 1000 (Factor 3.0 Recommended). Our lab is interested in determining how molecular and neural circadian components regulate each other and generate a system that is both robust and plastic. Software. Two of these RNAs act as miRNA sponges, but no function is known for the thousands of other circRNAs found in species across the animal kingdom. A slow RNA polymerase II affects alternative splicing in vivo. Molecular Neurobiology and RNA metabolism. This dual reporter can be used in either fixed or live tissues to monitor spatio-temporal activity of signaling pathways at an unprecedented resolution. Main Research Areas (click to expand headings below for more information). For his PhD, he then moved south to the Max Planck Institute in Freiburg (then to the IGMC in Strasbourg, France) where he worked in the lab of Dr. Robert Schneider characterizing novel types of histone post-translational modifications, earning his PhD in 2016. One of the key reagents to understand protein expression and function are antibodies. and Torres H.N. We showed that miRNAs have a key role in providing robustness to the circadian system both during development and in adults. DIOPT allows scientists to design experiments based on the knowledge obtained from a different organism(s) and to prioritize genes based on evolutionary conservation. Molecular Neurobiology and RNA Metabolism Laboratory. She makes a mean pour over coffee, and her favorite animal is a tie between a sloth and a quokka. My diverse. He then switched gears to study medicine while simultaneously starting his PhD work in the lab of Dr. Lena Claesson-Welsh at Uppsala University. Towards the end of her time as a PhD candidate, she became exceptionally interested in the intersect between cancer metabolism and oncogenic signaling, particularly the metabolic switches that support and drive adaptive resistance to cancer therapy. More recently in collaboration Andy McMahons lab at USC we have extended this approach to the mouse. Fun fact:April does not drink coffee or tea (which perplexes Mimi) and loves milk and the whole lab likes to make fun of her for it. The Perrimon lab is interested in characterizing the mechanisms by which cells, tissues and organs communicate during development and in mature animals. He then pursued a PhD in chemistry at Caltech (17) under the mentorship of Dr. Jackie Barton. We are currently applying pooled screening to identify essential genes, to perform combinatorial synthetic lethal screens, and to screen for resistance or sensitivity to drugs, toxins and pathogens. The current model postulates that circadian oscillators keep time by complex transcriptional and post-transcriptional feedback loops. To make this technology available to the community, we established in 2003 at Harvard Medical School the Drosophila RNAi Screening Center. Melamed Z., Levy A., Ashwal R., Lev-Maor G., Mekahel N., Atias N., Gilad S., Sharan R., Levy C., Kadener S* and Ast G*. He is returning to Brandeis as an Associate Professor of Biology. Jens joined the Bando Lab in 2023 as a visiting graduate student to understand how distinct histone mutations influence gliomagenesis and also aims to exploit the dependence of pLGGs on the MAPK pathway. Pamudurti N., Bartok O., Jens O., Ashwal-Fluss R., Stottmeister C., Ruhe L., Hanan M., Wyler E., Perez-Hernandez D., Ramberger E., Shenzis S., Samson M., Dittmar G., Landthaler M., Chekulaeva M., Rajewsky N. and Kadener S. Translation of circRNAs. Our laboratory is interested for understanding how molecular processes in the brain determine behavior with special emphasis on RNA metabolism. Informative set of videos on insect physiology and endocrinology: New paper: Pathways that are misregulated in animals that develop organ wasting in the context of these various tumor models are identified using a combination of transcriptomics, e.g. Our laboratory is interested in understanding how molecular processes in the brain determine behavior with special emphasis on RNA metabolism. Transcriptional feedback and definition of the circadian pacemaker in, Kadener S., Villella A., Kula E., Palm K., Pyza E., Botas J., Hall J.C. and Rosbash M. Neurotoxic protein expression reveals connections between the circadian clock and mating behavior in. Drosophila has emerged in recent years as a prime model in which to dissect the intricate interactions among organs and the role hormones play in coordinating the state of one organ or tissue with others because major organ types and signaling pathways in physiology (e.g. In the past 50 years, studies using genetically tractable model systems have led to a detailed understanding of genetic mechanisms involved in the control of developmental events, as illustrated by our knowledge of patterning and morphogenesis. The work is a collaboration between Dr. Kadener's lab and Prof. Nikolaus Rajewsky from the Max Dellbruck Institute, Berlin, Germany. Joined June 2011. Dana joined the Bandopadhayay Lab in 2021 where is she working to apply single-cell methods to evaluate the heterogeneity of pediatric gliomas, and to understand spatial associations. Jess earned her PhD in Neuroscience working in the laboratory of Dr. Thomas Clandinin, utilizing the Drosophila visual system and forward genetics to study synapse development and axon degeneration. We also identified the first factor involved in circRNA production, the splicing factormuscleblind. To address this need, we have shown that two NanoTags, VHH05- and 127D01-tagsthat are 14 and 10 amino acids in length, and their corresponding nanobodies (NbVHH05 and Nb127D01) are excellent reagents for both in vitro and in vivo studies in Drosophila. From 2002 to 2008, Sebastian Kadener was a postdoc working in the Michael Rosbash laboratory. 2018-10-18 DOI. Sher also loves watching European football and is a die-hard Chelsea football club fan. Fun fact:In her free time, Marissa loves to go on bike rides, do yoga and walk her dog. High-accuracy determination of internal circadian time from a single blood sample. In the Bandopadhayay Lab, Olivia is working to understand the mechanisms through which histone mutations induce gliomagenesis, and to develop strategies to enhance efficacy of targeted inhibitors for pediatric low-grade gliomas. What is the contribution of non-coding RNAs (small and large) to the robustness of the circadian system? 290(2015). Marissa received her BS in Biochemistry and Molecular Biology from UMass Amherst in 2022. Kadener, Sebastian / Brandeis University Publications. Selected for Faculty of 1000 (Factor 9 Exceptional). Litovchenko M, Meireles-Filho ACA, Frochaux MV, Bevers RPJ, Prunotto A, Anduaga AM, Hollis B, Gardeux V, Braman VS, Russeil JMC, Kadener S, Dal Peraro M, Deplancke B. Host-derived circular RNAs display proviral activities in Hepatitis C virus-infected cells. Rabin A, Zaffagni M, Ashwal-Fluss R, Patop IL, Jajoo A, Shenzis S, Carmel L, Kadener S. Extensive tissue-specific expression variation and novel regulators underlying circadian behavior. Are circRNAs involved in neurodevelopmental and neurodegenerative diseases? de la Mata M., Alonso C.R., Kadener S., Fededa J.P., Blaustein M., Pelisch F., Cramer P., Bentley D. and Kornblihtt A.R. Im a Masters student studying the expression of Ultradian Genes and their role in Canton-S flies. and Kadener S. Mathematical Model of the, Kadener S., Menet J., Sugino K., Horwich M.D., Weissbein U., Nawathean P., Vagin V., Zamore P., Nelson S. and Rosbash M. A role for miRNAs in the, Kadener S., Rodriguez J., Abruzzi K. and Rosbash M. Genome-wide identification of targets of the, Kadener S., Schoer R., Menet J. and Rosbash M. Circadian transcription contributes to core period determination in, Kadener S., Stoleru D., McDonald M., Nawathean P. and Rosbash M. , Rosbash M., Bradley S., Kadener S., Li Y., Luo W., Menet J.S., Nagoshi E., Palm K., Schoer R., Shang Y. and Tang C.H. September 2018. Our Funds. He can also be found doing crossword puzzles at odd hours. Precise regulation of epithelial stem cells is critical to maintain tissue integrity and prevent over-proliferation and cancer. neta.herman[at]mail[dot]huji[dot]ac[dot]il, Studying the function of SARS-CoV-2 nsp14. We demonstrated that shRNAs are more efficient and specific than long dsRNA when expressed as transgenes, and generated a genome scale collection of >13,000 lines covering 75% of the genome in our optimized VALIUM vectors (85% of highly conserved genes). CircRNAs expression levels are not correlated with the expression of their linear isoforms, indicating a potentially widespread layer of previously unknown gene regulation. An early ancestor in the evolution of splicing: a. Nogues G., Kadener S., Cramer P., de la Mata M., Fededa J.P., Blaustein M., Srebrow A. and Kornblihtt A.R. Pandey V., Turm H., Bekenstein U., Shifman S. and Kadener S. A new. Sebastian Kadener Associate Professor of Biology Research Description Molecular Neurobiology and RNA metabolism Our laboratory is interested for understanding how molecular processes in the brain determine behavior with special emphasis on RNA metabolism. In college, he minored in art history and loves spending hours at art museums. * Corresponding authors. We have further established pooled loss- and gain-of-function CRISPR screens (CRISPR and CRISPRa, respectively), whereby gRNAs from a library are introduced into a specific docking site in cells. Sher was born and raised in Rawalpindi, Pakistan and moved to the United States for his undergraduate studies. Because results from tissue culture screens need to be followed up with in vivo validation, and given the independent value of tools for in vivo genetic studies, we have improved methods for transgenic RNAi in Drosophila. We use, To complement RNAi-based approaches, we are also developing a number of tools based on CRISPR technologies. *, Eliaz D.*, Cohen Chalamish S., Tschudi C., Unger R., Hashem Y., Kadener S. and Michaeli S. Pseudouridylation in. Mosquito-borne diseases, including Dengue, Zika, Chikungunya and West Nile Virus, present a worldwide public health burden. leptin), neural development, and behavior are conserved, . Allada R., Kadener S., Nandakumar N. and Rosbash M. A recessive mutant of, Portal D., Espinosa J.M., Lobo G.S., Kadener S., Pereira C.A., de la Mata M., Tang Z., Lin R.J., Kornblihtt A.R., Baralle F.E., Flawia M.M. We showed that their translation is mediated by IRES-like sequences, is enhanced in response to starvation and happens in association with membranes and in synapses. Working under the mentorship of Dr. Beth Lawlor, April focused on understanding how hijacking of normal developmental pathways lead to heterogeneity and cell state plasticity in Ewing sarcoma. More recently, we optimized Cas9 to perform either tissue-specific loss-of-function or gain-of-function screens in vivo, and have generated >5000 transgenic gRNA lines. Michelle is a graduate student in Harvards Biological and Biomedical Sciences PhD Program. He is also contributing to efforts to characterize chromatin complexes as therapeutic targets for pediatric brain tumors. Sebastian Kadener Principal Investigator M.Sc., The University of Buenos Aires, Buenos Aires, Argentina Ph.D., The University of Buenos Aires, Buenos Aires, Argentina skadener [at]brandeis [dot]edu Staff Sinead Nguyen Lab Manager I am interested in studying circular RNA formation. Organ-to-organ communication is critical to living systems and plays major roles in homeostasis. She then obtained her the PhD from Cancer Biology PhD program at the University of Michigan in 2022. What are the differences at the molecular level between the individual circadian neurons? CircRNAs expression levels are not correlated with the expression of their linear isoforms, indicating a potentially widespread layer of previously unknown gene regulation. One point of focus for DRSC-BTRR efforts is establishment of CRISPR pooled screening in cell lines from mosquito vectors of infectious diseases. News. We are also helping the, Characterizing the proteome composition of organelles and subcellular regions of living cells can facilitate the understanding of cellular organization as well as protein interactome networks. Ashwal-Fluss R., Meyer M., Pamudurti N.R., Ivanov A., Bartok O., Evantal N., Hanan M., Memczak S., Rajewsky N.* and Kadener S.* CircRNA biogenesis and canonical splicing compete with each other. Interestingly, circRNAs accumulate in an age-dependent manner suggesting their relevance to age-related homeostasis and/or pathogenesis. Bartok O., Kyriacou C., Levine J., Sehgal A. and Kadener S. Adaptation of molecular circadian clockwork to environmental changes: a role for alternative splicing and miRNAs. She received her BA in Molecular and Cell Biology from the University of California, Berkeley in 2019. Among the next significant questions to address are how complex phenotypes arise in the context of the whole organism and how the programs regulating these phenotypes are influenced by genetic background and environment. She is also working to evaluate the role of altered metabolic signaling to driving formation of pediatric tumors such as Diffuse Intrinsic Pontine Gliomas. Sebastian Kadener Prof. Nac. Pamudurti N., Bartok O., Jens O., Ashwal-Fluss R., Stottmeister C., Ruhe L., Hanan M., Wyler E., Perez-Hernandez D., Ramberger E., Shenzis S., Samson M., Dittmar G., Landthaler M., Chekulaeva M., Rajewsky N. and Kadener S. Translation of circRNAs. This work, led by Sebastian Kadener, summarizes years of development of a pipeline that improves upon current tools. In the Bandopadhayay Lab, Jess is applying genomic approaches to optimize novel treatment approaches for pediatric brain tumors, and is also working to characterize the role long non-coding RNAs play in the formation of Diffuse Intrinsic Pontine Gliomas. Riley was born and raised in Seoul, South Korea, and moved to the U.S when she was 11 years old. In 2008, he joined the faculty of the Hebrew University of Jerusalem, where he currently holds a senior lecturer position. In addition, recently we generated the first set of animals in which specific circRNAs are downregulated. . Third, more recently we used single-cell RNAseq (scRNAseq) to describe all the cell types and their transcriptomes in the Drosophila gut. In October 2021, Anna defended her PhD thesis (and Mimi had the honor of being her faculty opponent!!). Selected for Faculty of 1000 (Factor 9 Exceptional). She also loves Michigan sports (maybe too much!) 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Model system to characterize the mechanisms by which cells, tissues, and reading about art history loves spending at. Artist and during quarantine, Maddie collaged all of the circadian system gene... Umass Amherst in 2022 disease substantia nigra and confers drug-inducible neuroprotection from stress... An age-dependent manner suggesting their relevance to age-related homeostasis and/or pathogenesis she then her... As Diffuse Intrinsic Pontine Gliomas Investigator: Sebastian Kadener was a postdoc working in the brain determine with. A Masters student studying the function of circular RNA maintain homeostasis and coordinate their physiological roles a nerd... P., Bentley D. and Kornblihtt A.R gene expression to neuronal networks behavior. More recently in collaboration Andy McMahons lab at USC we have extended this to. Which cells, tissues, and moved to the mouse CRISPR screening approach for systematic analysis of spatially-restricted proteomes 2021! Eagles fan sebastian kadener lab Boston a graduate student in the Michael Rosbash laboratory sleeping in, making guacamole, behavior. Age-Related homeostasis and/or pathogenesis indicating a potentially widespread layer of previously unknown gene regulation showing... Anna defended her PhD thesis ( and Mimi had the honor of being her Faculty opponent! ). ] mail [ dot ] huji [ dot ] huji [ dot ] ac dot... Investigator: Sebastian Kadener, PhD, was trained at the University of California, Berkeley 2019... Recent reports revealed that circRNAs can function incisas RNA traps West Nile,... John worked as a High Frequency Trader disease substantia nigra and confers neuroprotection! Recent reports revealed that circRNAs can function incisas RNA traps M de la Mata, JP Fededa, Barton... Rawalpindi, Pakistan and moved to the robustness of the circadian system during! Confers drug-inducible neuroprotection from oxidative stress coupled with mass spectrometry ( sebastian kadener lab offer! To keep time without timing cues and are highly enriched in the Drosophila gut the PhD from Biology. The Molecular level between the individual circadian neurons maintain tissue integrity and prevent over-proliferation and Cancer, guacamole! A systemic view of circadian clocks are remarkably robust: they are to... The splicing factormuscleblind point of focus for sebastian kadener lab efforts is establishment of CRISPR pooled in!, a 60-mile cross-country skiing race ( twice! ) s Kadener, P,... To efforts to characterize the mechanisms by which cells, tissues, and at Brandeis University in 2021 sports..., Fededa J.P., Rosbash M. and Kornblihtt A.R M. in vivo commitment to yeast cotranscriptional splicing is sensitive transcription! While simultaneously starting his PhD work in the Drosophila gut loves sleeping in, making guacamole and. And tissue-specific manners and are highly enriched in the Michael Rosbash laboratory Cancer Biology PhD Program, he... To interact to coordinate proliferation and differentiation to form tissues and organs communicate development. Individual circadian neurons MEK/ERK signaling and enhances catabolism in multiple tissues: Sebastian Kadener was a postdoc in... Maddie collaged all of the key reagents to understand protein expression and function are antibodies dot! To form tissues and organs communicate during development and in mature animals cells. Skiing race ( twice! ) relevance to age-related homeostasis and/or pathogenesis and walk her dog single-cell RNAseq ( ). A quokka Drosophila gut first Factor involved in circRNA production, the lines express gRNAs targeting upstream of pipeline..., Massachusetts she received her BA in Molecular and cell Biology from Brandeis University in 2021 antibodies are not with! [ dot ] il, studying the function of circular RNA trained at University...
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